Congratulations to Morgan Ludwicki who defended her PhD thesis on July 12, 2019! Her thesis focused on manipulation of the ubiquitin-proteasome pathway to achieve targeted silencing of cellular proteins as a reliable and customizable strategy for remodeling the mammalian proteome. Specifically, Morgan developed a new class of engineered "ubiquibodies" that are based on a bacterial E3 ubiquitin ligase. These ubiquibodies enabled broad-spectrum proteome editing in living cells and were also capable of protein knockdown in mice following delivery as mRNA-nanoplex formulations. Morgan is now a postdoctoral researcher in the Department of Pharmacology at the University of Minnesota.
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